منابع مشابه
Sertoli-cell prostaglandin synthesis
The synthesis of prostanoids by the Sertoli cell was assessed as part of a study on the role of vitamin E in maintaining spermatogenesis. Analyses of eicosanoid synthesis from endogenous substrate were carried out using freshly isolated Sertoli-cell-enriched preparations from both pre-pubertal and adult rats fed purified diets with and without vitamin E, as well as cells carried in primary cult...
متن کاملRole of Local Prostaglandin Synthesis
Address all correspondence to Dr. Frederick R. DeRubertis. Received for publication 1 April 1983 and in revised form 28 June 1983. lonic segments from indomethacin-treated rats resulted in persistent suppression of iPGE and mucosal cAMP, as well as persistent enhancement of [3H]dThd incorporation into mucosal DNA. However, incubation of colonic segments from control rats (no in vivo drug exposu...
متن کاملGlomerulonephritis and Cellular Regulation of Prostaglandin Synthesis
Prostaglandins, hormone-like substances initially isolated from human semen in 1930, got their name from the presumption that they predominately come from the prostate gland (von Euler 1936). In fact, prostaglandins are lipid mediators generated by a wide variety of cell types and tissues. Being derivatives of 20 carbon fatty acids, their common feature is 20carbon skeleton which includes 5-mem...
متن کاملProstaglandin E2 Synthesis in C6 Glioma Cells
Prostaglandin E2 (PGE2) plays an important role in immunosuppression and tumor growth. PGE2 inhibitors such as aspirin and indomethacin suppress experimental tumor growth. Little is known of the relationship between PGE2 synthesis in brain tumors and the dose of aspirin or indomethacin. The present study was undertaken to evaluate the effect of different doses of aspirin and indomethacin on PGE...
متن کاملVascular prostaglandin synthesis: the early days.
Prostacyclin (PGI2) and thromboxane (TxA2) labile cyclooxygenase (COX) products via PGH2 were identified in biological fluids by the ingenious application of the principle of parallel pharmacological assays developed by John Vane. Either organ perfusates or circulating blood superfuse bioassay tissues arranged in a cascade. Tissues were selected based on specificity of responses to targeted eic...
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ژورنال
عنوان ژورنال: Nature
سال: 1978
ISSN: 0028-0836,1476-4687
DOI: 10.1038/271787b0